BCL is a research project that uses Internet-connected computers to do research in Biochemical Library Fields (BCL).
Research in our laboratory seeks to fuse computational and experimental efforts to investigate proteins, the fundamental molecules of biology, and their interactions with small molecule substrates, therapeutics, or probes. We develop computational methods with three major ambitions in mind: 1) to enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses; 2) design proteins with novel structure and/or function to explore novel approaches to protein therapeutics and deepen our understanding of protein folding pathways, and 3) understand the relation between chemical structure and biological activity quantitatively in order to design more efficient and more specific drugs. Crucial for our success is the experimental validation of our computational approaches which we pursue in our laboratory or in collaboration with other scientists.
Current research applications focus on new approaches to a) drug and probe development for neurodegenerative disorders and diseases including Schizophrenia, Alzheimer's, and Parkinson’s, b) understanding the structural determinants of antidepressant binding to neurotransmitter transporters, c) cardiac arrhythmia as caused by the complex interplay of potassium channel regulation and drug interactions, d) multidrug resistance in cancer and bacterial cells related to multidrug transporter proteins, and e) structural basis of viral infections and antibody activity.
BCL is based at Vanderbilt University
and hosted by Information Technology Services
Home Page: http://boinc.vanderbilt.edu/bcl/
Active but is not issuing Work Units very often.
The project supports the following Applications:
Windows 32bits only.
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Home Page: http://androinc.net/
This project is very controversial as to its legitimacy and is currently Down as at 26 Aug 2011.
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