I had to reboot a win7 machine running 7.2.23. When it came back up, all the projects that were set to NO NEW WORK, were changed to allow work. I have ~50 project attached, but only ~5 were set to allow work. So my queue was filled with all kinds of tasks I didn't want. Also, all the local settings were reset to default. For example, all the Activity settings were changed back to "...based on preferences".
I am not sure if this was a BOINC bug, or some other random windows issue. But good lord, what a mess! Good thing I caught it after only about 15 minutes.