Description: BCL is a research project that uses Internet-connected computers to do research in Biochemical Library Fields (BCL).
Research in our laboratory seeks to fuse computational and experimental efforts to investigate proteins, the fundamental molecules of biology, and their interactions with small molecule substrates, therapeutics, or probes. We develop computational methods with three major ambitions in mind: 1) to enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses; 2) design proteins with novel structure and/or function to explore novel approaches to protein therapeutics and deepen our understanding of protein folding pathways, and 3) understand the relation between chemical structure and biological activity quantitatively in order to design more efficient and more specific drugs. Crucial for our success is the experimental validation of our computational approaches which we pursue in our laboratory or in collaboration with other scientists.
Current research applications focus on new approaches to a) drug and probe development for neurodegenerative disorders and diseases including Schizophrenia, Alzheimer's, and Parkinson’s, b) understanding the structural determinants of antidepressant binding to neurotransmitter transporters, c) cardiac arrhythmia as caused by the complex interplay of potassium channel regulation and drug interactions, d) multidrug resistance in cancer and bacterial cells related to multidrug transporter proteins, and e) structural basis of viral infections and antibody activity.
Institution: BCL is based at
Vanderbilt University and hosted by
Information Technology Services.
Home Page: http://boinc.vanderbilt.edu/bcl/
Project Status: Active but is not issuing Work Units very often.
Client Programs: The project supports the following Applications:
Windows 32bits only.
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Home Page: http://androinc.net/
Project Status This project is very controversial as to its legitimacy and is currently Down as at 26 Aug 2011.
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Re: Hello
Linux is better for some projects, just as windows is better for others, it really depends on the hardware and the chosen projects you want to run, ideally
purplecfh Yesterday, 08:09 PM