FightMalaria@Home: Progress Report

We have collected the experiments into groups, each aimed at a separate paper to be submitted to an open-access journal in the near future.

• A - Docking of MalariaBox compounds against the P. fal. proteome (MMV_400) - Exp=A,Ap,1p,2p,4p,6p
• B - Using vHTS to find the malarial targets of repurposed drugs (NPC) - Exp=8p-11p
• C - FightMalaria@Home – using vHTS to find targets for hit compounds (MMV_full) - Exp=B,Bp,3p,5p,7p,12p-15p
• D - FightMalaria@Home update – the effect of flexible active sites on vHTS (all) - Exp=16p-44p E - Using BOINC to identify novel antimalarial compounds (ZINC, CycloPs) - Exp=45p-47p

We have over 4 million results thus far, and % completion is as follows:

• A - 78%
• B - 20%
• C - 1%
• D - 0% E - 0%

Progress has slowed as we're now docking larger molecules with more rotatable bonds.

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