Over the years, I have had situations where the mounting hole for a motherboard does not sign up with the hole on the chassis. Sometimes the form factor is different, putting a CEB mobo into a chassis that only supports ATX, for example. I recently put a Chinese knock-off ATX mobo into an ATX chassis, but the mobo was missing a mounting hole in the middle. The chassis had the metal stand-off screw socket in place. So my choice is to

1) remove the stand-off, and also allow flex of the mobo. This gives me bad vibes when I have to insert DIMMs or GPUs, depending on the location of this issue.

or

2) leave the stand-off in place, and allow it to rub the various solder contacts on the back of the mobo

How do you all deal with this situation? Recommendations?