My Titan, which runs at 1071 MHz posts about 5.2 TFLOPS. I have had it installed in a PCIe x1 2.0 slot since i got it. Works perfectly fine
For gaming, again it wouldn't saturate even a 2.0 x16 slot. At least not on it's own. As i mentioned several posts back, there is no more Xfire bridge on these GPUs. All info is passed between the cards via the PCIe bus. I imagine running quad Xfire on a PCIe 2.0 bus would definitely cause some lag because of this, but 3.0 would have room left to spare.
The *effective* bandwidth of PCIe 3.0 is 985 MB/s per lane = 15.39 GB/s @ x16. To use it all, a single GPU running a 1080p monitor would have to achieve 1,992 frames per second.